The phrase most commonly refers to the 1997 film starring Robert Downey Jr., Heather Graham, and Natasha Gregson Wagner. However, it also identifies a popular long-running radio morning show in South Carolina. 1. Film: Two Girls and a Guy (1997)

This is a prominent local morning show based in Charleston, South Carolina, hosted by .

In social media and pop culture, the "two girls and a guy" grouping is a common trope often discussed in terms of friendship and relationship dynamics: