Ts.zip

: This is a model for how nucleic acids fold where a single nucleation site (often just one or two base pairs) forms first, followed by a rapid, sequential "zipping" of the remaining base pairs. Significance of TSzipcap T cap S sub z i p end-sub

represents a less structured state compared to the experimental transition state ( TSexpcap T cap S sub e x p end-sub ts.zip

values, scientists can determine if a molecule folds via a "stack-based" measure (requiring adjacent base pairs) or a more flexible "nucleation" model. : This is a model for how nucleic