: Helen eventually visited Seattle, where she met Alex's "person," Meredith Grey . This was a pivotal moment for Alex, as it bridged his difficult past with his successful present.

: After years of no contact, Alex and Jo Wilson traveled to Iowa to find Helen. They discovered she was stable, taking her medication, and working at a library.

“The moment between Helen and Mer, when both of them acknowledged how important Meredith is to Alex was specially sweet and emotional for me...” Reddit · r/greysanatomy · 7 years ago

Helen Karev (portrayed by Lindsay Wagner and Emily Rutherfurd) suffered from , which deeply impacted Alex’s upbringing. Because of her condition, Alex essentially raised himself and his two younger siblings, Aaron and Amber.

: As a teenager, Alex was her primary caregiver, ensuring she took her medication to manage her delusions.

: For much of his adult life, Alex maintained a distant but financially supportive relationship with her, often feeling the trauma of his childhood. Key Storylines