Mirna.7z Apr 2026

: It generally acts as a tumor suppressor . Its downregulation is linked to increased proliferation and metastasis in glioblastoma, lung, breast, and colorectal cancers by failing to inhibit oncogenic pathways like EGFR/PI3K/Akt .

: Its levels are controlled post-transcriptionally by "sponges" like circular RNA ciRS-7 (also known as CDR1as), which contains over 70 binding sites for miR-7 and can effectively quench its activity. Role in Pathophysiology Mirna.7z

miR-7 is preferentially expressed in neuroendocrine tissues, specifically the and pancreas . : It generally acts as a tumor suppressor

The dysregulation of miR-7 is a hallmark of several major pathologies: Mirna.7z