Fiona Landers, a nurse who worked at the infamous Saeki house in Tokyo, brings the curse back to her home in America, leading to a tragic family massacre.

True to the franchise's roots, the film utilizes a non-linear storytelling approach, weaving together three distinct timelines centered around a cursed house at in Pennsylvania.

Real estate agents Peter and Nina Spencer discover the curse while attempting to sell the property, while an elderly couple, the Mathesons, move in to deal with terminal illness and dementia.

Director Nicolas Pesce took a "holistic" approach to the film’s mythology. Rather than just remaking the previous films, he drew inspiration from the entire Ju-On canon, including short films, manga, novels, and even video games.