He is most famous in the entertainment world for his decade-long collaboration with the rock band Tool , providing the iconic, multi-dimensional "x-ray" artwork for albums like Lateralus and 10,000 Days . His art is a staple at electronic music festivals and Burning Man, where it serves as a visual language for spiritual and communal experiences.

Those who engage with Grey’s lifestyle and events often describe the experience as transformative or deeply religious in nature.

Critics often describe his style as "psychedelic realism". His work is praised for its scientific and medical precision—partially a result of his five years working at Harvard Medical School—merged with a "super-natural" view of humanity.