The story culminates in a final assault on Wilder's mountain fortress. After battling through endless waves of mercenaries and even attack helicopters, 50 Cent defeats both Kamal and Wilder. He eventually recovers his skull and ensures he gets paid, solidifying his mantra of "Get Rich or Die Tryin'" in a literal war zone.

As 50 Cent and his chosen G-Unit partner fight through the city, they discover that the skull is more than just a piece of "boneyard bling". It is an ancient relic tied to a much larger conflict involving:

The game begins after 50 Cent and G-Unit perform a massive concert in a war-torn urban zone. When 50 demands his , the local promoter, Anwar, reveals he doesn't have the cash. After some heavy persuasion, Anwar instead gives 50 a "priceless" diamond-and-pearl encrusted human skull as collateral. The Theft: "Bitch Took My Skull!"

Almost immediately after leaving the meeting, 50 Cent is ambushed by a paramilitary group led by a woman named . She steals the skull and flees, prompting 50’s famous mission directive: "Bitch took my skull!". From this point on, the narrative becomes a relentless pursuit of Leila and her superior, the terrorist warlord Said Kamal , to retrieve the stolen artifact. The Conflict: A Global Conspiracy

The skull is actually a key to a massive hidden fortune that Wilder and Kamal are trying to secure. The Conclusion: Getting Paid

The story of is an over-the-top action narrative centered on Curtis "50 Cent" Jackson and the G-Unit (Lloyd Banks, Tony Yayo, and DJ Whoo Kid) as they wage war across an unnamed Middle Eastern country to recover a stolen treasure . The Setup: Payment in Bling

A mysterious figure named Wilder is eventually revealed to be the true mastermind behind the regional chaos.