The .rar extension indicates this was likely a compressed file containing (such as high-resolution figures, gene expression tables, or raw data) hosted on an institutional or personal site. If you are looking for specific data from that archive, you may need to check the "Supporting Information" section of the Wiley publication page.
Developmental Dynamics , Volume 244, Issue 3 (November 24, 2014). 24227.rar
The identifier appears to refer to a specific archived dataset or supplement associated with the scientific paper "Input overload: Contributions of retinoic acid signaling feedback to retinoid homeostasis" (published in Developmental Dynamics ). Full Paper Details The identifier appears to refer to a specific
The paper explores how retinoic acid (RA) signaling uses feedback loops to maintain stable levels of Vitamin A metabolites, specifically examining the role of Retinoic Acid Receptors (RARs) and enzymes like Cyp26. Content Summary The research highlights that while direct activation of
A version of the manuscript is also available through PMC (National Library of Medicine) .
The research highlights that while direct activation of RA pathway genes via RAREs is understood, the mechanisms for negative feedback and suppression are still largely hypothetical. Accessing the Full Document