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: The researchers found that this combination triggers a "vaso-occlusive" event—essentially a controlled blockage of the blood vessels feeding the tumor—which leads to tumor cell death.

: The treatment demonstrated significant effectiveness in causing lung tumor regression in experimental models.

In environmental science, the number appears as in Volume 384 of the Journal of Environmental Management (2025). 125535

: This highlights a potential "therapeutic repurposing" of sickle cell biology to combat cancer by starving tumors of their oxygen and nutrient supply. Alternative Reference

The number primarily refers to a medical research paper titled "Exogenous sickle erythrocytes combined with vascular disruption trigger disseminated tumor vaso-occlusion and lung tumor regression" . Article Overview: JCI Insight 125535 : The researchers found that this combination triggers

Published in on April 4, 2019, this research investigates a novel approach to treating solid tumors by leveraging the properties of sickle red blood cells.

: The study uses "exogenous" (externally introduced) sickle red blood cells in combination with a vascular-disrupting agent to target the blood supply of tumors. : This highlights a potential "therapeutic repurposing" of

: "The impact of public eco-concern on urban eco-efficiency: A dual perspective analysis of net effect and configuration." Authors : Chao Wang and Jinbo Jiang.